Study of Hepatitis B Virus (hbv) Genotypes in Kermanshah Province, West of Iran
نویسندگان
چکیده
Hepatitis B virus (HBV), the prototype member of the family hepadnaviridae, is a human pathogen, causing the serious liver disease. The virus is the major cause of chronic hepatitis cirrhosis, and hepatocellular carcinoma worldwide. HBV has been classified into eight genotypes, which vary in geographic distribution. The aim of this study was to recognize the HBV genotypes in hepatitis B surface antigen (HBsAg)-positive carriers in west of Iran. In this study, one hundred HBsAg-positive carriers were used. Genotypes of HBV were recognized by nested-PCR that combined by restriction fragment length polymorphism (RFLP) technique. Eighty six out of hundred samples were positive-PCR and were used for HBV genotyping. Recognized genotypes were D and B, with frequency of eighty five and one cases (out of eighty six samples) respectively, while no result was obtained in other fourteen samples. This study indicated that predominant genotype of HBV in west of Iran is genotype D, while genotype B is very rare in this region.
منابع مشابه
Determination of Hepatitis B Virus Genotypes in Yazd, Central Province of Iran
Background and Aims: Hepatitis B virus (HBV) infects the liver and causes acute and chronic hepatitis, hepatocellular carcinoma and cirrhosis. HBV has been divided to eight genotypes (A–H) and subgenotypes of A, B, C and F. For the first time, we determined HBV genotypes in infected samples by INNO-LiPA method in Yazd, central province of Iran. Materials and Methods: This study was performed...
متن کاملDetection of SENV Virus in Healthy, Hepatitis B- and Hepatitis C-Infected Individuals in Yazd Province, Iran
Background: SEN virus (SENV) is the latest virus proposed as a cause of unknown hepatitis cases. Among nine detected genotypes of the virus, genotypes D and H are more frequent in hepatitis cases of unknown origin. The aim of this study was to determine the frequency of SENV-D and SENV-H genotypes in the sera of healthy individuals and hepatitis B and C patients. Methods: Totally, 200 serum sam...
متن کاملDistribution of Genotypes of B and C Hepatitis Viruses in Guilan Province
Today, chronic viral hepatitis is considered as a public health problem in the world. Totally, 5% of the world population, especially in Asia and Africa suffer from this problem. The prevalence of acute hepatitis in America is 0.1-0.2 percent, 50% of those with hepatitis C (HCV) and 5-10% of them with hepatitis B (HCV) develop chronic hepatitis. Determining HBV and HCV genotypes is important to...
متن کاملHepatitis B Virus Surface Antigen Variants Clustered Within Immune Epitopes in Chronic Hepatitis B Carriers from Hormozgan Province, South of Iran
Objective(s) The aim of this study was to characterize the hepatitis B virus surface protein genotypes and sequence variations among hepatitis B virus surface antigen (HBsAg) positive chronic patients in Hormozgan province, south of Iran. Materials and Methods A total of 8 patients enrolled in this study. The surface gene was amplified and directly sequenced. Genotypes and nucleotide/amino a...
متن کاملHepatitis B virus Genotypes in West Azarbayjan Province, Northwest Iran
BACKGROUND Infections caused by Hepatitis B are one of the world health's most serious problems. According to assessments, nearly 500,000 to 1.2 million people die each year due to chronic hepatitis, cirrhosis of the liver and hepatocellular carcinoma. Hepatitis B is one of the diseases which can be transferred through blood and its products. Clinical importance of genotypes of hepatitis B viru...
متن کامل